If you look at your installed Resident Evil 4 directory, you generally will not find a layout.bin file sitting next to bio4.exe . The file’s job ends the moment the installation finishes. (If a layout.bin file is present in your installed game folder, it is usually an accidental leftover from a bad drag-and-drop mod installation, and it can be safely deleted).
Which you are modding (2005 PC, Ultimate HD Edition, or console ports?) Layout.bin File For Resident Evil 4