Meyd-964 Jun 2026

| Study | Species | Dose (mg kg⁻¹) | Duration | No‑Observed‑Adverse‑Effect Level (NOAEL) | Key Findings | |-------|---------|----------------|----------|------------------------------------------|--------------| | Acute toxicity (single dose) | Mouse | 2000 | 14 d | — | LD₅₀ > 2000 mg kg⁻¹ (limit test). | | 28‑day repeat‑dose (GLP) | Rat | 5, 15, 45 | QD PO | 15 mg kg⁻¹ | Dose‑related hepatic vacuolization at 45 mg kg⁻¹; reversible after 2‑week recovery. | | 28‑day repeat‑dose (GLP) | Cynomolgus monkey | 2, 6, 12 | QD PO | 6 mg kg⁻¹ | Mild, reversible elevations in ALT/AST at 12 mg kg⁻¹; no histopathological lesions at ≤ 6 mg kg⁻¹. | | Genotoxicity (Ames, micronucleus) | N/A | — | — | Negative | No mutagenic activity in bacterial reverse‑mutation assay; negative in in‑vitro micronucleus test (human lymphocytes). | | Cardiac safety (hERG) | In‑vitro patch clamp | — | — | IC₅₀ > 30 µM | No significant inhibition of hERG current at concentrations up to 30 µM. |

The story follows Sayama Ai as a new mother. One day, she boards a packed train during rush hour, struggling to push her stroller. She endures scornful looks from other passengers as she makes her way to deliver a bento lunch to her husband. However, as she returns home, a man's hand begins to grope her. Overwhelmed and burdened, she is unable to resist. To make matters worse, her body, which has become unbearably sensitive after childbirth, begins to betray her, as it "started to seek out the man" despite her distress. This sets the stage for a scenario where public harassment leads to a reluctant and conflicted physical awakening. | Study | Species | Dose (mg kg⁻¹)

Liora felt tears streaming down her face as she whispered, “We are not the first to seek knowledge, and we will not be the last. The echo of their hopes and fears lives on in us.” | | Genotoxicity (Ames, micronucleus) | N/A |